Mutation of copper binding sites on cellular prion protein abolishes its inhibitory action on NMDA receptors in mouse hippocampal neurons

We have previously reported that cellular prion protein (PrP(C)) can down-regulate NMDA receptor activity and in a copper dependent manner. Here, we employed AAV9 to introduce murine cellular prion protein into mouse hippocampal neurons in primary cultures from PrP null mice to determine the role of...

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Detalles Bibliográficos
Autores principales: Huang, Sun, Black, Stefanie A., Huang, Junting, Stys, Peter K., Zamponi, Gerald W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Micro Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287767/
https://www.ncbi.nlm.nih.gov/pubmed/34281567
http://dx.doi.org/10.1186/s13041-021-00828-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287767/
https://www.ncbi.nlm.nih.gov/pubmed/34281567
http://dx.doi.org/10.1186/s13041-021-00828-0

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