SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction

The multidomain non-structural protein 3 (Nsp3) is the largest protein encoded by coronavirus (CoV) genomes and several regions of this protein are essential for viral replication. Of note, SARS-CoV Nsp3 contains a SARS-Unique Domain (SUD), which can bind Guanine-rich non-canonical nucleic acid stru...

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Detalles Bibliográficos
Autores principales: Lavigne, Marc, Helynck, Olivier, Rigolet, Pascal, Boudria-Souilah, Rofia, Nowakowski, Mireille, Baron, Bruno, Brülé, Sébastien, Hoos, Sylviane, Raynal, Bertrand, Guittat, Lionel, Beauvineau, Claire, Petres, Stéphane, Granzhan, Anton, Guillon, Jean, Pratviel, Geneviève, Teulade-Fichou, Marie-Paule, England, Patrick, Mergny, Jean-Louis, Munier-Lehmann, Hélène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287907/
https://www.ncbi.nlm.nih.gov/pubmed/34232992
http://dx.doi.org/10.1093/nar/gkab571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287907/
https://www.ncbi.nlm.nih.gov/pubmed/34232992
http://dx.doi.org/10.1093/nar/gkab571

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