Triplex-forming properties and enzymatic incorporation of a base-modified nucleotide capable of duplex DNA recognition at neutral pH

The sequence-specific recognition of duplex DNA by unmodified parallel triplex-forming oligonucleotides is restricted to low pH conditions due to a necessity for cytosine protonation in the third strand. This has severely restricted their use as gene-targeting agents, as well as for the detection an...

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Detalles Bibliográficos
Autor principal: Rusling, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287925/
https://www.ncbi.nlm.nih.gov/pubmed/34233006
http://dx.doi.org/10.1093/nar/gkab572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287925/
https://www.ncbi.nlm.nih.gov/pubmed/34233006
http://dx.doi.org/10.1093/nar/gkab572

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