Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2

Poly (ADP-ribose) polymerase inhibitor (PARPi)-based therapies initially reduce tumor burden but eventually lead to acquired resistance in cancer patients with BRCA1 or BRCA2 mutation. To understand the potential PARPi resistance mechanisms, we performed whole-genome CRISPR screens to discover genet...

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Detalles Bibliográficos
Autores principales: Tang, Mengfan, Pei, Guangsheng, Su, Dan, Wang, Chao, Feng, Xu, Srivastava, Mrinal, Chen, Zhen, Zhao, Zhongming, Chen, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287926/
https://www.ncbi.nlm.nih.gov/pubmed/34197614
http://dx.doi.org/10.1093/nar/gkab540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287926/
https://www.ncbi.nlm.nih.gov/pubmed/34197614
http://dx.doi.org/10.1093/nar/gkab540

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