A type III-A CRISPR–Cas system mediates co-transcriptional DNA cleavage at the transcriptional bubbles in close proximity to active effectors

Many type III CRISPR–Cas systems rely on the cyclic oligoadenylate (cOA) signaling pathway to exert immunization. However, LdCsm, a type III-A lactobacilli immune system mediates efficient plasmid clearance in spite of lacking cOA signaling. Thus, the system provides a good model for detailed charac...

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Detalles Bibliográficos
Autores principales: Lin, Jinzhong, Shen, Yulong, Ni, Jinfeng, She, Qunxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287949/
https://www.ncbi.nlm.nih.gov/pubmed/34197611
http://dx.doi.org/10.1093/nar/gkab590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287949/
https://www.ncbi.nlm.nih.gov/pubmed/34197611
http://dx.doi.org/10.1093/nar/gkab590

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