Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA

Deciphering translation is of paramount importance for the understanding of many diseases, and antibiotics played a pivotal role in this endeavour. Blasticidin S (BlaS) targets translation by binding to the peptidyl transferase center of the large ribosomal subunit. Using biochemical, structural and...

Descripción completa

Detalles Bibliográficos
Autores principales: Powers, Kyle T, Stevenson-Jones, Flint, Yadav, Sathish K N, Amthor, Beate, Bufton, Joshua C, Borucu, Ufuk, Shen, Dakang, Becker, Jonas P, Lavysh, Daria, Hentze, Matthias W, Kulozik, Andreas E, Neu-Yilik, Gabriele, Schaffitzel, Christiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287960/
https://www.ncbi.nlm.nih.gov/pubmed/34157102
http://dx.doi.org/10.1093/nar/gkab532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287960/
https://www.ncbi.nlm.nih.gov/pubmed/34157102
http://dx.doi.org/10.1093/nar/gkab532

Ejemplares similares