GGGCTA repeats can fold into hairpins poorly unfolded by replication protein A: a possible origin of the length-dependent instability of GGGCTA variant repeats in human telomeres

Human telomeres are composed of GGGTTA repeats and interspersed with variant repeats. The GGGCTA variant motif was identified in the proximal regions of human telomeres about 10 years ago and was shown to display a length-dependent instability. In parallel, a structural study showed that four GGGCTA...

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Detalles Bibliográficos
Autores principales: Chatain, Jean, Blond, Alain, Phan, Anh Tuân, Saintomé, Carole, Alberti, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287962/
https://www.ncbi.nlm.nih.gov/pubmed/34214172
http://dx.doi.org/10.1093/nar/gkab518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287962/
https://www.ncbi.nlm.nih.gov/pubmed/34214172
http://dx.doi.org/10.1093/nar/gkab518

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