Bispecific Antibody Armed Metabolically Enhanced Headless CAR T Cells

Adoptive T cell therapies for solid tumors is challenging. We generated metabolically enhanced co-activated-T cells by transducing intracellular co-stimulatory (41BB, ICOS or ICOS-27) and CD3ζ T cell receptor signaling domains followed by arming with bispecific antibodies (BiAbs) to produce armed “H...

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Detalles Bibliográficos
Autores principales: Thakur, Archana, Scholler, John, Kubicka, Ewa, Bliemeister, Edwin T., Schalk, Dana L., June, Carl H., Lum, Lawrence G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288104/
https://www.ncbi.nlm.nih.gov/pubmed/34290709
http://dx.doi.org/10.3389/fimmu.2021.690437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288104/
https://www.ncbi.nlm.nih.gov/pubmed/34290709
http://dx.doi.org/10.3389/fimmu.2021.690437

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