Synthesis, potential antitumor activity, cell cycle analysis, and multitarget mechanisms of novel hydrazones incorporating a 4-methylsulfonylbenzene scaffold: a molecular docking study

Hydrazone is a bioactive pharmacophore that can be used to design antitumor agents. We synthesised a series of hydrazones (compounds 4–24) incorporating a 4-methylsulfonylbenzene scaffold and analysed their potential antitumor activity. Compounds 6, 9, 16, and 20 had the most antitumor activity with...

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Detalles Bibliográficos
Autores principales: Abdel-Aziz, Alaa A.-M., El-Azab, Adel S., AlSaif, Nawaf A., Obaidullah, Ahmad J., Al-Obaid, Abdulrahman M., Al-Suwaidan, Ibrahim A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288134/
https://www.ncbi.nlm.nih.gov/pubmed/34266349
http://dx.doi.org/10.1080/14756366.2021.1924698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288134/
https://www.ncbi.nlm.nih.gov/pubmed/34266349
http://dx.doi.org/10.1080/14756366.2021.1924698

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