ptFVa (Pseudonaja Textilis Venom-Derived Factor Va) Retains Structural Integrity Following Proteolysis by Activated Protein C

OBJECTIVE: The Australian snake venom ptFV (Pseudonaja textilis venom-derived factor V) variant retains cofactor function despite APC (activated protein C)-dependent proteolysis. Here, we aimed to unravel the mechanistic principles by determining the role of the absent Arg306 cleavage site that is r...

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Detalles Bibliográficos
Autores principales: Schreuder, Mark, Liu, Xiaosong, Cheung, Ka Lei, Reitsma, Pieter H., Nicolaes, Gerry A.F., Bos, Mettine H.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Basic Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288481/
https://www.ncbi.nlm.nih.gov/pubmed/34162230
http://dx.doi.org/10.1161/ATVBAHA.121.316038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288481/
https://www.ncbi.nlm.nih.gov/pubmed/34162230
http://dx.doi.org/10.1161/ATVBAHA.121.316038

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