CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration

RNA-targeting CRISPR system Cas13 offers an efficient approach for manipulating RNA transcripts in vitro. In this perspective, we provide a proof-of-concept demonstration that Cas13-mediated Vegfa knockdown in vivo could prevent the development of laser-induced CNV in mouse model of Age-related macu...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Changyang, Hu, Xinde, Tang, Cheng, Liu, Wenjia, Wang, Shaoran, Zhou, Yingsi, Zhao, Qimeng, Bo, Qiyu, Shi, Linyu, Sun, Xiaodong, Zhou, Haibo, Yang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288881/
https://www.ncbi.nlm.nih.gov/pubmed/34692105
http://dx.doi.org/10.1093/nsr/nwaa033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288881/
https://www.ncbi.nlm.nih.gov/pubmed/34692105
http://dx.doi.org/10.1093/nsr/nwaa033

Ejemplares similares