Cargando…

CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration

RNA-targeting CRISPR system Cas13 offers an efficient approach for manipulating RNA transcripts in vitro. In this perspective, we provide a proof-of-concept demonstration that Cas13-mediated Vegfa knockdown in vivo could prevent the development of laser-induced CNV in mouse model of Age-related macu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Changyang, Hu, Xinde, Tang, Cheng, Liu, Wenjia, Wang, Shaoran, Zhou, Yingsi, Zhao, Qimeng, Bo, Qiyu, Shi, Linyu, Sun, Xiaodong, Zhou, Haibo, Yang, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Perspectives
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288881/ https://www.ncbi.nlm.nih.gov/pubmed/34692105 http://dx.doi.org/10.1093/nsr/nwaa033

Ejemplares similares

Programmable RNA Targeting Using CasRx in Flies
por: Buchman, Anna B., et al.
Publicado: (2020)

Methods for in vitro CRISPR/CasRx-Mediated RNA Editing
por: Chuang, Yu-Fan, et al.
Publicado: (2021)

Engineered Extracellular Vesicle‐Delivered CRISPR/CasRx as a Novel RNA Editing Tool
por: Li, Tianwen, et al.
Publicado: (2023)

RNA targeting using CasRx can prevent aminoglycoside-induced hearing loss
por: Bofill-De Ros, Xavier
Publicado: (2022)

CRISPR-CasRx Targeting LncRNA LINC00341 Inhibits Tumor Cell Growth in vitro and in vivo
por: Li, Chunjing, et al.
Publicado: (2021)

A Sensitive, Rapid, and Portable CasRx-based Diagnostic Assay for SARS-CoV-2
por: Brogan, Daniel J, et al.
Publicado: (2020)

CRISPR/CasRx Proof-of-Concept for RNA Degradation: A Future Tool against RNA Viruses?
por: Perez-SanJose, Diana, et al.
Publicado: (2021)

Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing
por: Zheng, Ziwen, et al.
Publicado: (2022)

Specific knockdown of Htra2 by CRISPR-CasRx prevents acquired sensorineural hearing loss in mice
por: Guo, Yang, et al.
Publicado: (2022)

Precise and efficient silencing of mutant Kras(G12D) by CRISPR-CasRx controls pancreatic cancer progression
por: Jiang, Wang, et al.
Publicado: (2020)

Evaluating the Impact of gRNA SNPs in CasRx Activity for Reducing Viral RNA in HCoV-OC43
por: Mayes, Cathryn Michelle, et al.
Publicado: (2022)

CRISPR/CasRx-Mediated RNA Knockdown Reveals That ACE2 Is Involved in the Regulation of Oligodendroglial Cell Morphological Differentiation
por: Kato, Yukino, et al.
Publicado: (2022)

Enhanced RNA knockdown efficiency with engineered fusion guide RNAs that function with both CRISPR-CasRx and hammerhead ribozyme
por: Zhan, Yonghao, et al.
Publicado: (2023)

Homology-directed repair in mouse cells increased by CasRx-mediated knockdown or co-expressing Kaposi’s sarcoma-associated herpesvirus ORF52
por: Pan, Hong, et al.
Publicado: (2019)

Progression of subclinical choroidal neovascularization in age-related macular degeneration
por: Heiferman, Michael J., et al.
Publicado: (2019)

Choroidal Modifications Preceding the Onset of Macular Neovascularization in Age-Related Macular Degeneration
por: Arrigo, Alessandro, et al.
Publicado: (2021)

Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos
por: Wei, Yu, et al.
Publicado: (2021)

Choroidal endothelial and macrophage gene expression in atrophic and neovascular macular degeneration
por: Voigt, Andrew P, et al.
Publicado: (2022)

Pemafibrate prevents choroidal neovascularization in a mouse model of neovascular age-related macular degeneration
por: Lee, Deokho, et al.
Publicado: (2023)

POLYPOIDAL CHOROIDAL NEOVASCULARIZATION VERSUS TYPE 1 CHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION: A Fractal Analysis Study
por: Serra, Rita, et al.
Publicado: (2022)

Intravitreal Bevacizumab for Choroidal Neovascularization Secondary to Non-Age-Related Macular Degeneration
por: Salehipour, Masoud, et al.
Publicado: (2010)

Chronic, Systemic Interleukin-18 Does Not Promote Macular Degeneration or Choroidal Neovascularization
por: Canna, Scott W., et al.
Publicado: (2017)

Development of focal choroidal excavation in non-neovascular age related macular degeneration with pachy-choroid features
por: Banaee, Touka, et al.
Publicado: (2019)

Comparison of cytokine levels in the aqueous humor of polypoidal choroidal vasculopathy and neovascular age-related macular degeneration patients
por: Zhou, Huiying, et al.
Publicado: (2020)

Growth of nonexudative macular neovascularization in age-related macular degeneration: an indicator of biological lesion activity
por: Wang, Yusong, et al.
Publicado: (2022)

Conbercept for Treatment of Neovascular Age-Related Macular Degeneration and Visual Impairment due to Diabetic Macular Edema or Pathologic Myopia Choroidal Neovascularization: A Systematic Review and Meta-Analysis
por: Zhou, Pengxiang, et al.
Publicado: (2021)

Macular Hole following Intravitreal Bevacizumab Injection in Choroidal Neovascularization Caused by Age-Related Macular Degeneration
por: Moisseiev, Elad, et al.
Publicado: (2010)

ANGPTL4 influences the therapeutic response of patients with neovascular age-related macular degeneration by promoting choroidal neovascularization
por: Qin, Yu, et al.
Publicado: (2022)

Associations between the Complement System and Choroidal Neovascularization in Wet Age-Related Macular Degeneration
por: Jensen, Emilie Grarup, et al.
Publicado: (2020)

Activation of a Quiescent Choroidal Neovascularization in a Patient with Age-Related Macular Degeneration
por: Matysik-Woźniak, Anna, et al.
Publicado: (2021)

Genetic Association between MMP9 and Choroidal Neovascularization in Age-Related Macular Degeneration
por: Sohn, Elliott H., et al.
Publicado: (2021)

The effect of intravitreal brolucizumab on choroidal thickness in patients with neovascular age-related macular degeneration
por: Bae, Ki Woong, et al.
Publicado: (2022)

Pan-Coronavirus CRISPR-CasRx Effector System Significantly Reduces Viable Titer in HCoV-OC43, HCoV-229E, and SARS-CoV-2
por: Mayes, Cathryn M., et al.
Publicado: (2023)

Thy-1 Regulates VEGF-Mediated Choroidal Endothelial Cell Activation and Migration: Implications in Neovascular Age-Related Macular Degeneration
por: Wang, Haibo, et al.
Publicado: (2016)

Lamellar macular hole formation following intravitreal bevacizumab injection for choroidal neovascularization by age-related macular degeneration
por: Torabi, Hamidreza, et al.
Publicado: (2018)

Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration
por: Zhao, Min, et al.
Publicado: (2019)

Combined Treatment of Photodynamic Therapy and Bevacizumab for Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
por: Kim, Hyun Woong, et al.
Publicado: (2011)

SOD2 gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
por: Kondo, Naoshi, et al.
Publicado: (2009)

Four-Year Outcome of Aflibercept for Neovascular Age-Related Macular Degeneration and polypoidal choroidal vasculopathy
por: Nishikawa, Keiichi, et al.
Publicado: (2019)

OPTICAL COHERENCE TOMOGRAPHY, FLUORESCEIN ANGIOGRAPHY, AND DIAGNOSIS OF CHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION
por: Gualino, Vincent, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_7e2l2okf55t139tmj41bn3t5dl