Decoupling gene functions from knockout effects by evolutionary analyses

Genic functions have long been confounded by pleiotropic mutational effects. To understand such genetic effects, we examine HAP4, a well-studied transcription factor in Saccharomyces cerevisiae that functions by forming a tetramer with HAP2, HAP3 and HAP5. Deletion of HAP4 results in highly pleiotro...

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Detalles Bibliográficos
Autores principales: Liu, Li, Liu, Mengdi, Zhang, Di, Deng, Shanjun, Chen, Piaopiao, Yang, Jing, Xie, Yunhan, He, Xionglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288921/
https://www.ncbi.nlm.nih.gov/pubmed/34692141
http://dx.doi.org/10.1093/nsr/nwaa079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288921/
https://www.ncbi.nlm.nih.gov/pubmed/34692141
http://dx.doi.org/10.1093/nsr/nwaa079

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