Mechanistic Insight into How PEGylation Reduces the Efficacy of pH-Sensitive Liposomes from Molecular Dynamics Simulations

[Image: see text] Liposome-based drug delivery systems composed of DOPE stabilized with cholesteryl hemisuccinate (CHMS) have been proposed as a drug delivery mechanism with pH-triggered release as the anionic form (CHSa) is protonated (CHS) at reduced pH; PEGylation is known to decrease this pH sen...

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Detalles Bibliográficos
Autores principales: Mahmoudzadeh, Mohammad, Magarkar, Aniket, Koivuniemi, Artturi, Róg, Tomasz, Bunker, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289284/
https://www.ncbi.nlm.nih.gov/pubmed/34096310
http://dx.doi.org/10.1021/acs.molpharmaceut.1c00122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289284/
https://www.ncbi.nlm.nih.gov/pubmed/34096310
http://dx.doi.org/10.1021/acs.molpharmaceut.1c00122

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