Cargando…
The Role of Cyclodextrins against Interface-Induced Denaturation in Pharmaceutical Formulations: A Molecular Dynamics Approach
[Image: see text] Protein-based pharmaceutical products are subject to a variety of environmental stressors, during both production and shelf-life. In order to preserve their structure, and, therefore, functionality, it is necessary to use excipients as stabilizing agents. Among the eligible stabili...
Autores principales: | Rospiccio, Marcello, Arsiccio, Andrea, Winter, Gerhard, Pisano, Roberto |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2021
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289300/ https://www.ncbi.nlm.nih.gov/pubmed/33999634 http://dx.doi.org/10.1021/acs.molpharmaceut.1c00135 |
Ejemplares similares
-
Mechanistic
Investigation of tert-Butanol’s Impact on
Biopharmaceutical Formulations: When
Experiments Meet Molecular Dynamics
por: Rospiccio, Marcello, et al.
Publicado: (2023) -
Force Field Parameterization for the Description of
the Interactions between Hydroxypropyl-β-Cyclodextrin and Proteins
por: Arsiccio, Andrea, et al.
Publicado: (2021) -
Effect of diffusion kinetics on the ice nucleation temperature distribution
por: Stratta, Lorenzo, et al.
Publicado: (2022) -
Protein Denaturants at Aqueous–Hydrophobic
Interfaces: Self-Consistent Correlation between Induced Interfacial
Fluctuations and Denaturant Stability at the Interface
por: Cui, Di, et al.
Publicado: (2014) -
A proximity-based in silico approach to identify redox-labile disulfide bonds: The example of FVIII
por: Arsiccio, Andrea, et al.
Publicado: (2022)