Compression of quantification uncertainty for scRNA-seq counts

MOTIVATION: Quantification estimates of gene expression from single-cell RNA-seq (scRNA-seq) data have inherent uncertainty due to reads that map to multiple genes. Many existing scRNA-seq quantification pipelines ignore multi-mapping reads and therefore underestimate expected read counts for many g...

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Detalles Bibliográficos
Autores principales: Van Buren, Scott, Sarkar, Hirak, Srivastava, Avi, Rashid, Naim U, Patro, Rob, Love, Michael I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289386/
https://www.ncbi.nlm.nih.gov/pubmed/33471073
http://dx.doi.org/10.1093/bioinformatics/btab001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289386/
https://www.ncbi.nlm.nih.gov/pubmed/33471073
http://dx.doi.org/10.1093/bioinformatics/btab001

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