DNA-RNA hybrids at DSBs interfere with repair by homologous recombination

DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome integrity. The readout of DSB repair may depend on whether DSBs occur at transcribed versus non-transcribed regions. Some studies have postulated that DNA-RNA hybrids form at DS...

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Detalles Bibliográficos
Autores principales: Ortega, Pedro, Mérida-Cerro, José Antonio, Rondón, Ana G, Gómez-González, Belén, Aguilera, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289408/
https://www.ncbi.nlm.nih.gov/pubmed/34236317
http://dx.doi.org/10.7554/eLife.69881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289408/
https://www.ncbi.nlm.nih.gov/pubmed/34236317
http://dx.doi.org/10.7554/eLife.69881

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