Cargando…
Trehalose Augments Neuron Survival and Improves Recovery from Spinal Cord Injury via mTOR-Independent Activation of Autophagy
Spinal cord injury (SCI) is a major cause of irreversible nerve injury and leads to serious tissue loss and neurological dysfunction. Thorough investigation of cellular mechanisms, such as autophagy, is crucial for developing novel and effective therapeutics. We administered trehalose, an mTOR-indep...
Autores principales: | Zhou, Kailiang, Chen, Huanwen, Xu, Huazi, Jia, Xiaofeng |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289614/ https://www.ncbi.nlm.nih.gov/pubmed/34336117 http://dx.doi.org/10.1155/2021/8898996 |
Ejemplares similares
-
Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway
por: Wu, Chenyu, et al.
Publicado: (2021) -
The Temporal Pattern, Flux, and Function of Autophagy in Spinal Cord Injury
por: Zhou, Kailiang, et al.
Publicado: (2017) -
Trehalose promotes the survival of random-pattern skin flaps by TFEB mediated autophagy enhancement
por: Wu, Hongqiang, et al.
Publicado: (2019) -
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress
por: Zhou, Kailiang, et al.
Publicado: (2020) -
Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway
por: Chen, Xu, et al.
Publicado: (2016)