Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity

Studying latent Mycobacterium tuberculosis (Mtb) infection has been limited by the lack of a suitable mouse model. We discovered that transient depletion of biotin protein ligase (BPL) and thioredoxin reductase (TrxB2) results in latent infections during which Mtb cannot be detected but that relapse...

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Detalles Bibliográficos
Autores principales: Su, Hongwei, Lin, Kan, Tiwari, Divya, Healy, Claire, Trujillo, Carolina, Liu, Yao, Ioerger, Thomas R., Schnappinger, Dirk, Ehrt, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Technical Advances and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289691/
https://www.ncbi.nlm.nih.gov/pubmed/34269789
http://dx.doi.org/10.1084/jem.20210332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289691/
https://www.ncbi.nlm.nih.gov/pubmed/34269789
http://dx.doi.org/10.1084/jem.20210332

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