Activity of tumor-associated macrophage depletion by CSF1R blockade is highly dependent on the tumor model and timing of treatment

Tumor-associated macrophages (TAMs) are abundant in solid tumors where they exhibit immunosuppressive and pro-tumorigenic functions. Inhibition of TAM proliferation and survival through CSF1R blockade has been widely explored as a cancer immunotherapy. To further define mechanisms regulating CSF1R-t...

Descripción completa

Detalles Bibliográficos
Autores principales: O’Brien, Sarah A., Orf, Jessica, Skrzypczynska, Katarzyna M., Tan, Hong, Kim, Jennie, DeVoss, Jason, Belmontes, Brian, Egen, Jackson G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289806/
https://www.ncbi.nlm.nih.gov/pubmed/33511454
http://dx.doi.org/10.1007/s00262-021-02861-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289806/
https://www.ncbi.nlm.nih.gov/pubmed/33511454
http://dx.doi.org/10.1007/s00262-021-02861-3

Ejemplares similares