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Activity of tumor-associated macrophage depletion by CSF1R blockade is highly dependent on the tumor model and timing of treatment

Tumor-associated macrophages (TAMs) are abundant in solid tumors where they exhibit immunosuppressive and pro-tumorigenic functions. Inhibition of TAM proliferation and survival through CSF1R blockade has been widely explored as a cancer immunotherapy. To further define mechanisms regulating CSF1R-t...

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Detalles Bibliográficos
Autores principales:	O’Brien, Sarah A., Orf, Jessica, Skrzypczynska, Katarzyna M., Tan, Hong, Kim, Jennie, DeVoss, Jason, Belmontes, Brian, Egen, Jackson G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289806/ https://www.ncbi.nlm.nih.gov/pubmed/33511454 http://dx.doi.org/10.1007/s00262-021-02861-3

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