Cargando…

Activity of tumor-associated macrophage depletion by CSF1R blockade is highly dependent on the tumor model and timing of treatment

Tumor-associated macrophages (TAMs) are abundant in solid tumors where they exhibit immunosuppressive and pro-tumorigenic functions. Inhibition of TAM proliferation and survival through CSF1R blockade has been widely explored as a cancer immunotherapy. To further define mechanisms regulating CSF1R-t...

Descripción completa

Detalles Bibliográficos
Autores principales:	O’Brien, Sarah A., Orf, Jessica, Skrzypczynska, Katarzyna M., Tan, Hong, Kim, Jennie, DeVoss, Jason, Belmontes, Brian, Egen, Jackson G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289806/ https://www.ncbi.nlm.nih.gov/pubmed/33511454 http://dx.doi.org/10.1007/s00262-021-02861-3

Ejemplares similares

Brief report: STING expressed in tumor and non-tumor compartments has distinct roles in regulating anti-tumor immunity
por: Kim, Jennie C., et al.
Publicado: (2022)

Generation of bone marrow chimeras using X-ray irradiation: comparison to cesium irradiation and use in immunotherapy
por: Eng, Jason, et al.
Publicado: (2020)

OncoVEX(mGM-CSF)expands tumor antigen-specific CD8+ T-cell response in preclinical models
por: Estrada, Juan, et al.
Publicado: (2023)

CSF1R Inhibition Depletes Tumor-Associated Macrophages and Attenuates Tumor Progression in a Mouse Sonic Hedgehog-Medulloblastoma Model
por: Tan, I-Li, et al.
Publicado: (2020)

Blockade of tumor-derived colony-stimulating factor 1 (CSF1) promotes an immune-permissive tumor microenvironment
por: Maldonado, Maria del Mar, et al.
Publicado: (2023)

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors
por: Arce Vargas, Frederick, et al.
Publicado: (2017)

Tumor-derived CSF-1 induces the NKG2D ligand RAE-1δ on tumor-infiltrating macrophages
por: Thompson, Thornton W, et al.
Publicado: (2018)

Radiation combined with macrophage depletion promotes adaptive immunity and potentiates checkpoint blockade
por: Jones, Keaton I, et al.
Publicado: (2018)

GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity
por: Ruffolo, Luis I, et al.
Publicado: (2022)

PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages
por: Kauffman, Kevin, et al.
Publicado: (2023)

Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes
por: Kuil, Laura E, et al.
Publicado: (2020)

Depletion of Tumor-Associated Macrophages Slows the Growth of Chemically Induced Mouse Lung Adenocarcinomas
por: Fritz, Jason M., et al.
Publicado: (2014)

Tumor Associated Macrophages: Origin, Recruitment, Phenotypic Diversity, and Targeting
por: Hourani, Tetiana, et al.
Publicado: (2021)

High Expression of CSF-1R Predicts Poor Prognosis and CSF-1R(high) Tumor-Associated Macrophages Inhibit Anti-Tumor Immunity in Colon Adenocarcinoma
por: Wang, Xingchao, et al.
Publicado: (2022)

Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer
por: Lin, WeiYu, et al.
Publicado: (2019)

Corrigendum: Depletion of Tumor-Associated Macrophages Slows the Growth of Chemically Induced Mouse Lung Adenocarcinomas
por: Fritz, Jason M., et al.
Publicado: (2015)

TGF-β blockade depletes T regulatory cells from metastatic pancreatic tumors in a vaccine dependent manner
por: Soares, Kevin C., et al.
Publicado: (2015)

Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease
por: Cook, Andrew D, et al.
Publicado: (2001)

CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization
por: Yang, Xiao, et al.
Publicado: (2020)

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages
por: Freedman, Tanya S, et al.
Publicado: (2015)

Genetic and Pharmacological Targeting of CSF-1/CSF-1R Inhibits Tumor-Associated Macrophages and Impairs BRAF-Induced Thyroid Cancer Progression
por: Ryder, Mabel, et al.
Publicado: (2013)

Clodronate-Liposome Mediated Macrophage Depletion Abrogates Multiple Myeloma Tumor Establishment In Vivo
por: Opperman, Khatora S., et al.
Publicado: (2019)

Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages
por: Smith, Bryan D., et al.
Publicado: (2021)

CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves
por: Martínez-Muriana, Anna, et al.
Publicado: (2016)

Imaging endogenous macrophage iron deposits reveals a metabolic biomarker of polarized tumor macrophage infiltration and response to CSF1R breast cancer immunotherapy
por: Leftin, Avigdor, et al.
Publicado: (2019)

Targeting CD89 on tumor-associated macrophages overcomes resistance to immune checkpoint blockade
por: Xu, Lijun, et al.
Publicado: (2022)

Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer
por: Di Mitri, Diletta, et al.
Publicado: (2019)

G‐CSF/GM‐CSF‐induced hematopoietic dysregulation in the progression of solid tumors
por: He, Kai, et al.
Publicado: (2022)

MYC regulates CSF1 expression via microRNA 17/20a to modulate tumor-associated macrophages in osteosarcoma
por: Nirala, Bikesh K., et al.
Publicado: (2023)

CSF1R methylation is a key regulatory mechanism of tumor-associated macrophages in hepatocellular carcinoma
por: Cui, Bin, et al.
Publicado: (2020)

CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8(+) T cells
por: Strachan, Debbie C, et al.
Publicado: (2013)

Shigella Mediated Depletion of Macrophages in a Murine Breast Cancer Model Is Associated with Tumor Regression
por: Galmbacher, Katharina, et al.
Publicado: (2010)

Depletion of tumor‐associated macrophages inhibits lung cancer growth and enhances the antitumor effect of cisplatin
por: Kawaguchi, Yo, et al.
Publicado: (2022)

Depletion of tumor-associated macrophages enhances the anti-tumor immunity induced by a Toll-like receptor agonist-conjugated peptide
por: Shen, Kuan-Yin, et al.
Publicado: (2014)

Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy
por: Wang, Stephanie J., et al.
Publicado: (2020)

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade
por: Stanczak, Michal A., et al.
Publicado: (2022)

Aging Leads to Increased Monocytes and Macrophages With Altered CSF-1 Receptor Expression and Earlier Tumor-Associated Macrophage Expansion in Murine Mesothelioma
por: Duong, Lelinh, et al.
Publicado: (2022)

Synergy of nanodiamond–doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells
por: Xu, Hua-Zhen, et al.
Publicado: (2021)

Vasoactive intestinal peptide blockade suppresses tumor growth by regulating macrophage polarization and function in CT26 tumor-bearing mice
por: Kittikulsuth, Wararat, et al.
Publicado: (2023)

Promotion of Tumor Invasion by Tumor-Associated Macrophages: The Role of CSF-1-Activated Phosphatidylinositol 3 Kinase and Src Family Kinase Motility Signaling
por: Dwyer, Amy R., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3qeb5t0lf42f1lgi6ktv78u0ba