Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

ABCG2 is a multidrug transporter that affects drug pharmacokinetics and contributes to multidrug resistance of cancer cells. In previously reported structures, the reaction cycle was halted by the absence of substrates or ATP, mutation of catalytic residues, or the presence of small-molecule inhibit...

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Detalles Bibliográficos
Autores principales: Yu, Qin, Ni, Dongchun, Kowal, Julia, Manolaridis, Ioannis, Jackson, Scott M., Stahlberg, Henning, Locher, Kaspar P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289821/
https://www.ncbi.nlm.nih.gov/pubmed/34282134
http://dx.doi.org/10.1038/s41467-021-24651-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289821/
https://www.ncbi.nlm.nih.gov/pubmed/34282134
http://dx.doi.org/10.1038/s41467-021-24651-2

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