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Pharmacological Inactivation of CatSper Blocks Sperm Fertilizing Ability Independently of the Capacitation Status of the Cells: Implications for Non-hormonal Contraception

Cation channel of sperm (CatSper), the main sperm-specific Ca(2+) channel, plays a key role in mammalian fertilization, and it is essential for male fertility, becoming an attractive target for contraception. Based on this, in the present work, we investigated the effects of CatSper inactivation on...

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Detalles Bibliográficos
Autores principales: Curci, Ludmila, Carvajal, Guillermo, Sulzyk, Valeria, Gonzalez, Soledad Natalia, Cuasnicú, Patricia S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290173/
https://www.ncbi.nlm.nih.gov/pubmed/34295893
http://dx.doi.org/10.3389/fcell.2021.686461