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Application of TGF-β1, TIMP-1 and TIMP-2 small interfering RNAs can alleviate CCl(4)-induced hepatic fibrosis in rats by rebalancing Th1/Th2 cytokines
The present study aimed to investigate the effects of TGF-β1, tissue inhibitor of metalloproteinase (TIMP)-1 small interfering (si)RNA and TIMP-2 siRNA on hepatic fibrosis in rats and explore the T helper (Th)1/Th2 balance. Moreover, IFN-γ, IL-4 and IL-13 are the main cytokines associated with Th1/T...
Autores principales: | Xue, Ying, Qian, Keli, Sun, Yinchun, Xiao, Lang, Shi, Xiaofeng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290469/ https://www.ncbi.nlm.nih.gov/pubmed/34335905 http://dx.doi.org/10.3892/etm.2021.10395 |
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