Tertiary sulphonamide derivatives as dual acting small molecules that inhibit LSD1 and suppress tubulin polymerisation against liver cancer

A series of tertiary sulphonamide derivatives were synthesised and evaluated for their antiproliferative activity against liver cancer cell lines (SNU-475, HepG-2, and Bel-7402). Among these tertiary sulphonamides, compound 17a displayed the best anti-liver cancer activity against Bel-7402 cells wit...

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Detalles Bibliográficos
Autores principales: Ding, Lijuan, Wei, Feng, Wang, Nanya, Sun, Yue, Wang, Qiang, Fan, Xia, Qi, Ling, Wang, Shudong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291071/
https://www.ncbi.nlm.nih.gov/pubmed/34281464
http://dx.doi.org/10.1080/14756366.2021.1917564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291071/
https://www.ncbi.nlm.nih.gov/pubmed/34281464
http://dx.doi.org/10.1080/14756366.2021.1917564

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