Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency

[Image: see text] Non-covalent inhibitors of the main protease (M(pro)) of SARS-CoV-2 having a pyridinone core were previously reported with IC(50) values as low as 0.018 μM for inhibition of enzymatic activity and EC(50) values as low as 0.8 μM for inhibition of viral replication in Vero E6 cells....

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Detalles Bibliográficos
Autores principales: Zhang, Chun-Hui, Spasov, Krasimir A., Reilly, Raquel A., Hollander, Klarissa, Stone, Elizabeth A., Ippolito, Joseph A., Liosi, Maria-Elena, Deshmukh, Maya G., Tirado-Rives, Julian, Zhang, Shuo, Liang, Zhuobin, Miller, Scott J., Isaacs, Farren, Lindenbach, Brett D., Anderson, Karen S., Jorgensen, William L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291137/
https://www.ncbi.nlm.nih.gov/pubmed/34408808
http://dx.doi.org/10.1021/acsmedchemlett.1c00326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291137/
https://www.ncbi.nlm.nih.gov/pubmed/34408808
http://dx.doi.org/10.1021/acsmedchemlett.1c00326

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