Development of New Benzylpiperazine Derivatives as σ(1) Receptor Ligands with in Vivo Antinociceptive and Anti-Allodynic Effects

[Image: see text] σ-1 receptors (σ(1)R) modulate nociceptive signaling, driving the search for selective antagonists to take advantage of this promising target to treat pain. In this study, a new series of benzylpiperazinyl derivatives has been designed, synthesized, and characterized for their affi...

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Detalles Bibliográficos
Autores principales: Romeo, Giuseppe, Bonanno, Federica, Wilson, Lisa L., Arena, Emanuela, Modica, Maria N., Pittalà, Valeria, Salerno, Loredana, Prezzavento, Orazio, McLaughlin, Jay P., Intagliata, Sebastiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291485/
https://www.ncbi.nlm.nih.gov/pubmed/34019387
http://dx.doi.org/10.1021/acschemneuro.1c00106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291485/
https://www.ncbi.nlm.nih.gov/pubmed/34019387
http://dx.doi.org/10.1021/acschemneuro.1c00106

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