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Molecular Details of a Coupled Binding and Folding Reaction between the Amyloid Precursor Protein and a Folded Domain

[Image: see text] Intrinsically disordered regions in proteins often function as binding motifs in protein–protein interactions. The mechanistic aspects and molecular details of such coupled binding and folding reactions, which involve formation of multiple noncovalent bonds, have been broadly studi...

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Detalles Bibliográficos
Autores principales: Jensen, Thomas M. T., Bartling, Christian R. O., Karlsson, O. Andreas, Åberg, Emma, Haugaard-Kedström, Linda M., Strømgaard, Kristian, Jemth, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291497/
https://www.ncbi.nlm.nih.gov/pubmed/34161732
http://dx.doi.org/10.1021/acschembio.1c00176