Enantioselective Catalytic Dearomative Addition of Grignard Reagents to 4-Methoxypyridinium Ions

[Image: see text] We describe a general catalytic methodology for the enantioselective dearomative alkylation of pyridine derivatives with Grignard reagents, allowing direct access to nearly enantiopure chiral dihydro-4-pyridones with yields up to 98%. The methodology involves dearomatization of in...

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Detalles Bibliográficos
Autores principales: Guo, Yafei, Castiñeira Reis, Marta, Kootstra, Johanan, Harutyunyan, Syuzanna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291581/
https://www.ncbi.nlm.nih.gov/pubmed/34306813
http://dx.doi.org/10.1021/acscatal.1c01544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291581/
https://www.ncbi.nlm.nih.gov/pubmed/34306813
http://dx.doi.org/10.1021/acscatal.1c01544

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