Cargando…

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer’s Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

[Image: see text] Alzheimer’s disease is the most common neurodegenerative disorder characterized by the pathological aggregation of amyloid-β (Aβ) peptide. A potential therapeutic intervention in Alzheimer’s disease is to enhance Aβ degradation by increasing the activity of Aβ-degrading enzymes, in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rofo, Fadi, Sandbaumhüter, Friederike A., Chourlia, Aikaterini, Metzendorf, Nicole G., Morrison, Jamie I., Syvänen, Stina, Andrén, Per E., Jansson, Erik T., Hultqvist, Greta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291608/ https://www.ncbi.nlm.nih.gov/pubmed/34170117 http://dx.doi.org/10.1021/acschemneuro.1c00303

Ejemplares similares

Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain
por: Rofo, Fadi, et al.
Publicado: (2021)

A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer’s Disease Mice
por: Rofo, Fadi, et al.
Publicado: (2022)

Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood–brain barrier shuttle scFv8D3
por: de la Rosa, Andrés, et al.
Publicado: (2022)

Blood–brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
por: Rofo, Fadi, et al.
Publicado: (2022)

Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer’s disease
por: Gustavsson, Tobias, et al.
Publicado: (2023)

Standardized Preclinical In Vitro Blood–Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways
por: Morrison, Jamie I., et al.
Publicado: (2023)

Label-Free Quantitative Thermal Proteome Profiling Reveals Target Transcription Factors with Activities Modulated by MC3R Signaling
por: Sandbaumhüter, Friederike A., et al.
Publicado: (2023)

Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer’s Disease
por: Meier, Silvio R., et al.
Publicado: (2021)

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
por: Hultqvist, Greta, et al.
Publicado: (2017)

Well-Plate μFASP for Proteomic Analysis of Single Pancreatic Islets
por: Sandbaumhüter, Friederike A., et al.
Publicado: (2022)

Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody
por: Syvänen, Stina, et al.
Publicado: (2018)

Enantioselective CE–MS analysis of ketamine metabolites in urine
por: Sandbaumhüter, Friederike A., et al.
Publicado: (2022)

RNA interactome capture in Escherichia coli globally identifies RNA-binding proteins
por: Stenum, Thomas Søndergaard, et al.
Publicado: (2023)

Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau
por: Banka, Vinay, et al.
Publicado: (2023)

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
por: Rofo, Fadi, et al.
Publicado: (2021)

Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
por: Meier, Silvio R., et al.
Publicado: (2018)

Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
por: Roshanbin, Sahar, et al.
Publicado: (2022)

Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
por: Fang, Xiaotian T., et al.
Publicado: (2017)

Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β
por: Sehlin, Dag, et al.
Publicado: (2017)

Engineered antibodies: new possibilities for brain PET?
por: Sehlin, Dag, et al.
Publicado: (2019)

Human Somatostatin SST(4) Receptor Transgenic Mice: Construction and Brain Expression Pattern Characterization
por: Nemes, Balázs, et al.
Publicado: (2021)

On The Rate and Extent of Drug Delivery to the Brain
por: Hammarlund-Udenaes, Margareta, et al.
Publicado: (2007)

Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates
por: Petersen, Inga, et al.
Publicado: (2023)

Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
por: Faresjö, Rebecca, et al.
Publicado: (2023)

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
por: Faresjö, Rebecca, et al.
Publicado: (2021)

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease
por: Gustavsson, Tobias, et al.
Publicado: (2020)

Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer’s Disease
por: Zyśk, Marlena, et al.
Publicado: (2019)

Chronic mild stress alters the somatostatin receptors in the rat brain
por: Faron-Górecka, A., et al.
Publicado: (2015)

Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-Aβ-Affibodies
por: Faresjö, Rebecca, et al.
Publicado: (2022)

The Current Status of Somatostatin-Interneurons in Inhibitory Control of Brain Function and Plasticity
por: Scheyltjens, Isabelle, et al.
Publicado: (2016)

Search strategy is regulated by somatostatin signaling and deep brain photoreceptors in zebrafish
por: Horstick, Eric J., et al.
Publicado: (2017)

The role of neuropeptide somatostatin in the brain and its application in treating neurological disorders
por: Song, You-Hyang, et al.
Publicado: (2021)

Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging
por: Schlein, Eva, et al.
Publicado: (2022)

Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis
por: Julku, Ulrika, et al.
Publicado: (2022)

Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
por: Syvänen, Stina, et al.
Publicado: (2020)

Activation of Brain Somatostatin Signaling Suppresses CRF Receptor-Mediated Stress Response
por: Stengel, Andreas, et al.
Publicado: (2017)

Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-K(ATP) channel pathway
por: Watamura, Naoto, et al.
Publicado: (2021)

ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein
por: Bonvicini, Gillian, et al.
Publicado: (2022)

Zero-Degree Celsius Capillary Electrophoresis Electrospray Ionization for Hydrogen Exchange Mass Spectrometry
por: Aerts, Jordan T., et al.
Publicado: (2022)

Electrochemically Etched Tapered-Tip Stainless-Steel Electrospray-Ionization Emitters for Capillary Electrophoresis–Mass Spectrometry
por: Aerts, Jordan T., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8os5m3ftnti84fqoano7og4j0s