Unexpected Substituent Effects in Spiro-Compound Formation: Steering N-Aryl Propynamides and DMSO toward Site-Specific Sulfination in Quinolin-2-ones or Spiro[4,5]trienones

[Image: see text] A highly substituent-dependent rearrangement allows for the novel and SOCl(2)-induced divergent synthesis of 3-methylthioquinolin-2-ones and 3-methylthiospiro[4.5]trienones through intramolecular electrophilic cyclization of N-aryl propyamides. DMSO acts as both solvent and sulfur...

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Detalles Bibliográficos
Autores principales: Li, Xiaoxian, Wang, Yuanxun, Ouyang, Yaxin, Yu, Zhenyang, Zhang, Beibei, Zhang, Jingran, Shi, Haofeng, Zuilhof, Han, Du, Yunfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291627/
https://www.ncbi.nlm.nih.gov/pubmed/34184892
http://dx.doi.org/10.1021/acs.joc.1c00775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291627/
https://www.ncbi.nlm.nih.gov/pubmed/34184892
http://dx.doi.org/10.1021/acs.joc.1c00775

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