Why are viral genomes so fragile? The bottleneck hypothesis

If they undergo new mutations at each replication cycle, why are RNA viral genomes so fragile, with most mutations being either strongly deleterious or lethal? Here we provide theoretical and numerical evidence for the hypothesis that genetic fragility is partly an evolutionary response to the multi...

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Detalles Bibliográficos
Autores principales: Merleau, Nono S. C., Pénisson, Sophie, Gerrish, Philip J., Elena, Santiago F., Smerlak, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291636/
https://www.ncbi.nlm.nih.gov/pubmed/34237053
http://dx.doi.org/10.1371/journal.pcbi.1009128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291636/
https://www.ncbi.nlm.nih.gov/pubmed/34237053
http://dx.doi.org/10.1371/journal.pcbi.1009128

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