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BCR activated CLL B cells use both CR3 (CD11b/CD18) and CR4 (CD11c/CD18) for adhesion while CR4 has a dominant role in migration towards SDF-1
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the western world. In previous studies, various proportion of patients was found to carry CD11b(+) or CD11c(+) B cells whose presence was an unfavourable prognostic factor. The exact mechanism however, how these receptors contribute...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291664/ https://www.ncbi.nlm.nih.gov/pubmed/34283878 http://dx.doi.org/10.1371/journal.pone.0254853 |