Development and validation of a platform reduced intact mass method for process monitoring of monoclonal antibody glycosylation during routine manufacturing

N-linked glycosylation is a primary source of heterogeneity associated with recombinant monoclonal antibodies and plays a key role in a myriad of drug properties associated with biological function. The glycosylation profile of recombinant monoclonal antibodies is influenced by an array of cell cult...

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Detalles Bibliográficos
Autores principales: Schilling, Michael, Feng, Pamela, Sosic, Zoran, Traviglia, Stacey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291849/
https://www.ncbi.nlm.nih.gov/pubmed/33201770
http://dx.doi.org/10.1080/21655979.2020.1842651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291849/
https://www.ncbi.nlm.nih.gov/pubmed/33201770
http://dx.doi.org/10.1080/21655979.2020.1842651

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