Optimization and Pharmacokinetic Evaluation of Synergistic Fenbendazole and Rapamycin Co-Encapsulated in Methoxy Poly(Ethylene Glycol)-b-Poly(Caprolactone) Polymeric Micelles

PURPOSE: We aimed to develop a nanocarrier formulation incorporating fenbendazole (FEN) and rapamycin (RAPA) with strong efficacy against A549 cancer cells. As FEN and RAPA are poorly soluble in water, it is difficult to apply them clinically in vivo. Therefore, we attempted to resolve this problem...

Descripción completa

Detalles Bibliográficos
Autores principales: Shin, Hee Ji, Jo, Min Jeong, Jin, Ik Sup, Park, Chun-Woong, Kim, Jin-Seok, Shin, Dae Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291852/
https://www.ncbi.nlm.nih.gov/pubmed/34295160
http://dx.doi.org/10.2147/IJN.S315782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291852/
https://www.ncbi.nlm.nih.gov/pubmed/34295160
http://dx.doi.org/10.2147/IJN.S315782

Ejemplares similares