Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

Epithelial tissues are primed to respond to insults by activating epithelial cell motility and rapid inflammation. Such responses are also elicited upon overexpression of the membrane-bound protease, Matriptase, or mutation of its inhibitor, Hai1. Unrestricted Matriptase activity also predisposes to...

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Detalles Bibliográficos
Autores principales: Ma, Jiajia, Scott, Claire A, Ho, Ying Na, Mahabaleshwar, Harsha, Marsay, Katherine S, Zhang, Changqing, Teow, Christopher KJ, Ng, Ser Sue, Zhang, Weibin, Tergaonkar, Vinay, Partridge, Lynda J, Roy, Sudipto, Amaya, Enrique, Carney, Tom J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291973/
https://www.ncbi.nlm.nih.gov/pubmed/34165081
http://dx.doi.org/10.7554/eLife.66596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291973/
https://www.ncbi.nlm.nih.gov/pubmed/34165081
http://dx.doi.org/10.7554/eLife.66596

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