A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling

Voltage-gated KCNQ1 channels contain four separate voltage-sensing domains (VSDs) and a pore domain (PD). KCNQ1 expressed alone opens when the VSDs are in an intermediate state. In cardiomyocytes, KCNQ1 co-expressed with KCNE1 opens mainly when the VSDs are in a fully activated state. KCNE1 also dra...

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Detalles Bibliográficos
Autores principales: Wu, Xiaoan, Perez, Marta E., Noskov, Sergei Yu, Larsson, H. Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292421/
https://www.ncbi.nlm.nih.gov/pubmed/34285340
http://dx.doi.org/10.1038/s42003-021-02418-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292421/
https://www.ncbi.nlm.nih.gov/pubmed/34285340
http://dx.doi.org/10.1038/s42003-021-02418-1

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