Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes

OBJECTIVE: The greatest genetic effect reported for systemic sclerosis (SSc) lies in the major histocompatibility complex (MHC) locus. Leveraging the largest SSc genome-wide association study, we aimed to fine-map this region to identify novel human leucocyte antigen (HLA) genetic variants associate...

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Detalles Bibliográficos
Autores principales: Acosta-Herrera, Marialbert, Kerick, Martin, Lopéz-Isac, Elena, Assassi, Shervin, Beretta, Lorenzo, Simeón-Aznar, Carmen Pilar, Ortego-Centeno, Norberto, Proudman, Susanna M, Hunzelmann, Nicolas, Moroncini, Gianluca, de Vries-Bouwstra, Jeska K, Orozco, Gisela, Barton, Anne, Herrick, Ariane L, Terao, Chikashi, Allanore, Yannick, Brown, Matthew A, Radstake, Timothy RDJ, Fonseca, Carmen, Denton, Christopher P, Mayes, Maureen D, Martin, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Systemic Sclerosis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292594/
https://www.ncbi.nlm.nih.gov/pubmed/34096881
http://dx.doi.org/10.1136/annrheumdis-2021-219884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292594/
https://www.ncbi.nlm.nih.gov/pubmed/34096881
http://dx.doi.org/10.1136/annrheumdis-2021-219884

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