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Ubiquitination Destabilizes Protein Sphingosine Kinase 2 to Regulate Glioma Malignancy
Gliomas are the most common and lethal malignant tumor in the central nervous system. The tumor oncogene sphingosine kinase 2 (SphK2) was previously found to be upregulated in glioma tissues and enhance glioma cell epithelial-to-mesenchymal transition through the AKT/β-catenin pathway. Nevertheless,...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292629/ https://www.ncbi.nlm.nih.gov/pubmed/34305532 http://dx.doi.org/10.3389/fncel.2021.660354 |