Cargando…

SPOP and OTUD7A Control EWS–FLI1 Protein Stability to Govern Ewing Sarcoma Growth

Chromosomal translocation results in development of an Ewing sarcoma breakpoint region 1‐Friend leukemia integration 1 (EWS–FLI1) fusion oncogene in the majority of Ewing sarcoma. The persistent dependence of the tumor for this oncoprotein points to EWS–FLI1 as an ideal drug target. Although EWS–FLI...

Descripción completa

Detalles Bibliográficos
Autores principales:	Su, Siyuan, Chen, Jianfeng, Jiang, Yao, Wang, Ying, Vital, Tamara, Zhang, Jiaming, Laggner, Christian, Nguyen, Kong T., Zhu, Zhichuan, Prevatte, Alex W., Barker, Natalie K., Herring, Laura E., Davis, Ian J., Liu, Pengda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292909/ https://www.ncbi.nlm.nih.gov/pubmed/34060252 http://dx.doi.org/10.1002/advs.202004846

Ejemplares similares

Downstream EWS/FLI1 - upstream Ewing's sarcoma
por: Kovar, Heinrich
Publicado: (2010)

Targeted Therapy for EWS-FLI1 in Ewing Sarcoma
por: Gong, Helong, et al.
Publicado: (2023)

The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma
por: Elzi, David J., et al.
Publicado: (2015)

Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma
por: Herrero-Martin, David, et al.
Publicado: (2011)

Epigenetic control of the EWS-FLI1 promoter in Ewing's sarcoma
por: Montoya, C., et al.
Publicado: (2020)

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma
por: Sankar, Savita, et al.
Publicado: (2012)

EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma
por: Cidre-Aranaz, Florencia, et al.
Publicado: (2015)

USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth
por: Gierisch, Maria E., et al.
Publicado: (2019)

EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma
por: Shi, Xianping, et al.
Publicado: (2020)

TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma
por: Seong, Bo Kyung A., et al.
Publicado: (2021)

One oncogene, several vulnerabilities: EWS/FLI targeted therapies for Ewing sarcoma
por: Flores, Guillermo, et al.
Publicado: (2021)

Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1
por: Chan, D, et al.
Publicado: (2003)

EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma
por: Fadul, John, et al.
Publicado: (2015)

Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting
por: Theisen, Emily R., et al.
Publicado: (2016)

EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells
por: Mutz, Cornelia N., et al.
Publicado: (2017)

A polypeptide from the junction region sequence of EWS-FLI1 inhibits Ewing’s sarcoma cells, interacts with the EWS-FLI1 and partner proteins
por: Thangaretnam, Krishna Priya, et al.
Publicado: (2017)

BCL11B Is Up-Regulated by EWS/FLI and Contributes to the Transformed Phenotype in Ewing Sarcoma
por: Wiles, Elizabeth T., et al.
Publicado: (2013)

Pharmacokinetic modeling optimizes inhibition of the ‘undruggable’ EWS-FLI1 transcription factor in Ewing Sarcoma
por: Hong, Sung-Hyeok, et al.
Publicado: (2013)

Ewing Sarcoma Cells Secrete EWS/Fli-1 Fusion mRNA via Microvesicles
por: Tsugita, Masanori, et al.
Publicado: (2013)

Targeting the epigenetic readers in Ewing Sarcoma inhibits the oncogenic transcription factor EWS/Fli1
por: Jacques, Camille, et al.
Publicado: (2016)

Precision diagnostics of Ewing’s sarcoma by liquid biopsy: circulating EWS-FLI1 fusion transcripts
por: Allegretti, Matteo, et al.
Publicado: (2018)

Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis
por: Molnar, Cristina, et al.
Publicado: (2022)

EWS/FLI1 Characterization, Activation, Repression, Target Genes and Therapeutic Opportunities in Ewing Sarcoma
por: Yasir, Muhammad, et al.
Publicado: (2023)

AtomNet-Aided OTUD7B Inhibitor Discovery and Validation
por: Chen, Jianfeng, et al.
Publicado: (2023)

Signature-Based Small Molecule Screening Identifies Cytosine Arabinoside as an EWS/FLI Modulator in Ewing Sarcoma
por: Stegmaier, Kimberly, et al.
Publicado: (2007)

Let-7a Is a Direct EWS-FLI-1 Target Implicated in Ewing's Sarcoma Development
por: De Vito, Claudio, et al.
Publicado: (2011)

A zebrafish transgenic model of Ewing’s sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis
por: Leacock, Stefanie W., et al.
Publicado: (2012)

Systems biology of Ewing sarcoma: a network model of EWS-FLI1 effect on proliferation and apoptosis
por: Stoll, Gautier, et al.
Publicado: (2013)

Preclinical Justification of pbi-shRNA EWS/FLI1 Lipoplex (LPX) Treatment for Ewing's Sarcoma
por: Rao, Donald D., et al.
Publicado: (2016)

Identification of two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma
por: Johnson, Kirsten M., et al.
Publicado: (2017)

EWS‐FLI1 regulates a transcriptional program in cooperation with Foxq1 in mouse Ewing sarcoma
por: Shimizu, Rikuka, et al.
Publicado: (2018)

Inhibition of HDACs reduces Ewing sarcoma tumor growth through EWS-FLI1 protein destabilization
por: Pedot, Gloria, et al.
Publicado: (2022)

EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma
por: Showpnil, Iftekhar A, et al.
Publicado: (2022)

The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma
por: Lu, Diana Y., et al.
Publicado: (2023)

SIX1 and EWS/FLI1 co-regulate an anti-metastatic gene network in Ewing Sarcoma
por: Hughes, Connor J., et al.
Publicado: (2023)

Preferential down-regulation of phospholipase C- β in Ewing's sarcoma cells transfected with antisense EWS-Fli-1
por: Dohjima, T, et al.
Publicado: (2000)

EWS/FLI Mediates Transcriptional Repression via NKX2.2 during Oncogenic Transformation in Ewing's Sarcoma
por: Owen, Leah A., et al.
Publicado: (2008)

Genomic EWS-FLI1 Fusion Sequences in Ewing Sarcoma Resemble Breakpoint Characteristics of Immature Lymphoid Malignancies
por: Berger, Manfred, et al.
Publicado: (2013)

Synthesis and Structure–Activity Relationship Studies of Small Molecule Disruptors of EWS-FLI1 Interactions in Ewing’s Sarcoma
por: Tosso, Perrer N., et al.
Publicado: (2014)

EWS-FLI1 positively regulates autophagy by increasing ATG4B expression in Ewing sarcoma cells
por: Lu, Qunshan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_i7vgom8e24brtvvmbmrjh1032d