Starch Nanoparticles for Enhancement of Oral Bioavailability of a Newly Synthesized Thienopyrimidine Derivative with Anti-Proliferative Activity Against Pancreatic Cancer

PURPOSE: This research aimed to improve water solubility and oral bioavailability of a newly synthesized thienopyrimidine derivative (TPD) with anti-pancreatic cancer activity by loading on starch nanoparticles (SNPs). METHODS: TPD was synthesized, purified and its ADME behavior was predicted using...

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Detalles Bibliográficos
Autores principales: Gardouh, Ahmed R, Srag El-Din, Ahmed S G, Salem, Mohamed S H, Moustafa, Yasser, Gad, Shadeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292977/
https://www.ncbi.nlm.nih.gov/pubmed/34305395
http://dx.doi.org/10.2147/DDDT.S321962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292977/
https://www.ncbi.nlm.nih.gov/pubmed/34305395
http://dx.doi.org/10.2147/DDDT.S321962

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