Beyond the Lactate Paradox: How Lactate and Acidity Impact T Cell Therapies against Cancer

T cell therapies, including CAR T cells, have proven more effective in hematologic malignancies than solid tumors, where the local metabolic environment is distinctly immunosuppressive. In particular, the acidic and hypoxic features of the tumor microenvironment (TME) present a unique challenge for...

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Detalles Bibliográficos
Autores principales: Tu, Violet Y., Ayari, Asma, O’Connor, Roddy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293081/
https://www.ncbi.nlm.nih.gov/pubmed/34203136
http://dx.doi.org/10.3390/antib10030025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293081/
https://www.ncbi.nlm.nih.gov/pubmed/34203136
http://dx.doi.org/10.3390/antib10030025

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