Structures of HIV-1 Neutralizing Antibody 10E8 Delineate the Mechanistic Basis of Its Multi-Peak Behavior on Size-Exclusion Chromatography

Antibody 10E8 is capable of effectively neutralizing HIV through its recognition of the membrane-proximal external region (MPER), and a suitably optimized version of 10E8 might have utility in HIV therapy and prophylaxis. However, 10E8 displays a three-peak profile on size-exclusion chromatography (...

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Detalles Bibliográficos
Autores principales: Do Kwon, Young, Wang, Xiangchun E., Bender, Michael F., Yang, Rong, Li, Yile, McKee, Krisha, Rawi, Reda, O’Dell, Sijy, Schneck, Nicole A., Shaddeau, Andrew, Zhang, Baoshan, Arnold, Frank J., Connors, Mark, Doria-Rose, Nicole A., Kwong, Peter D., Lei, Q. Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293163/
https://www.ncbi.nlm.nih.gov/pubmed/34200826
http://dx.doi.org/10.3390/antib10020023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293163/
https://www.ncbi.nlm.nih.gov/pubmed/34200826
http://dx.doi.org/10.3390/antib10020023

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