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Structures of HIV-1 Neutralizing Antibody 10E8 Delineate the Mechanistic Basis of Its Multi-Peak Behavior on Size-Exclusion Chromatography
Antibody 10E8 is capable of effectively neutralizing HIV through its recognition of the membrane-proximal external region (MPER), and a suitably optimized version of 10E8 might have utility in HIV therapy and prophylaxis. However, 10E8 displays a three-peak profile on size-exclusion chromatography (...
Autores principales: | Do Kwon, Young, Wang, Xiangchun E., Bender, Michael F., Yang, Rong, Li, Yile, McKee, Krisha, Rawi, Reda, O’Dell, Sijy, Schneck, Nicole A., Shaddeau, Andrew, Zhang, Baoshan, Arnold, Frank J., Connors, Mark, Doria-Rose, Nicole A., Kwong, Peter D., Lei, Q. Paula |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293163/ https://www.ncbi.nlm.nih.gov/pubmed/34200826 http://dx.doi.org/10.3390/antib10020023 |
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