FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires autocrine FGF21 signaling. Adipose-specific deletion of the FGF21 co-receptor β-Klotho renders mice unresponsive to β-adren...

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Detalles Bibliográficos
Autores principales: Abu-Odeh, Mohammad, Zhang, Yuan, Reilly, Shannon M., Ebadat, Nima, Keinan, Omer, Valentine, Joseph M., Hafezi-Bakhtiari, Maziar, Ashayer, Hadeel, Mamoun, Lana, Zhou, Xin, Zhang, Jin, Yu, Ruth T., Dai, Yang, Liddle, Christopher, Downes, Michael, Evans, Ronald M., Kliewer, Steven A., Mangelsdorf, David J., Saltiel, Alan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293281/
https://www.ncbi.nlm.nih.gov/pubmed/34192547
http://dx.doi.org/10.1016/j.celrep.2021.109331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293281/
https://www.ncbi.nlm.nih.gov/pubmed/34192547
http://dx.doi.org/10.1016/j.celrep.2021.109331

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