Cargando…

FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires autocrine FGF21 signaling. Adipose-specific deletion of the FGF21 co-receptor β-Klotho renders mice unresponsive to β-adren...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abu-Odeh, Mohammad, Zhang, Yuan, Reilly, Shannon M., Ebadat, Nima, Keinan, Omer, Valentine, Joseph M., Hafezi-Bakhtiari, Maziar, Ashayer, Hadeel, Mamoun, Lana, Zhou, Xin, Zhang, Jin, Yu, Ruth T., Dai, Yang, Liddle, Christopher, Downes, Michael, Evans, Ronald M., Kliewer, Steven A., Mangelsdorf, David J., Saltiel, Alan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293281/ https://www.ncbi.nlm.nih.gov/pubmed/34192547 http://dx.doi.org/10.1016/j.celrep.2021.109331

Ejemplares similares

Autocrine FGF1 signaling promotes glucose uptake in adipocytes
por: Nies, Vera J. M., et al.
Publicado: (2022)

Regulation of metabolism by a neuroendocrine FGF signaling pathway
por: Mangelsdorf, David J, et al.
Publicado: (2014)

Regulation of nutrient metabolism by nuclear receptor/FGF signaling pathways
por: Kliewer, Steven A, et al.
Publicado: (2012)

β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
por: Valentine, Joseph M., et al.
Publicado: (2022)

Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules
por: Song, No-Joon, et al.
Publicado: (2017)

FGF19 functions as autocrine growth factor for hepatoblastoma
por: Elzi, David J., et al.
Publicado: (2016)

Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230
por: Blackwell, Christina, et al.
Publicado: (2016)

FGF15/19 is required for adipose tissue plasticity in response to thermogenic adaptations
por: Morón-Ros, Samantha, et al.
Publicado: (2020)

FGF21 contributes to neuroendocrine control of female reproduction
por: Owen, Bryn M., et al.
Publicado: (2013)

Transcriptomic Analysis Reveals Fibroblast Growth Factor 11 (FGF11) Role in Brown Adipocytes in Thermogenic Regulation of Goats
por: Jiang, Tingting, et al.
Publicado: (2023)

Suppressive Effect of Autocrine FGF21 on Autophagy-Deficient Hepatic Tumorigenesis
por: Kim, Jinyoung, et al.
Publicado: (2022)

The Autocrine FGF/FGFR System in both Skin and Uveal Melanoma: FGF Trapping as a Possible Therapeutic Approach
por: Rezzola, Sara, et al.
Publicado: (2019)

The thermogenic circuit: Regulators of thermogenic competency and differentiation
por: Lynes, Matthew D., et al.
Publicado: (2015)

FGF21 Counteracts Alcohol Intoxication by Activating the Noradrenergic Nervous System
por: Choi, Mihwa, et al.
Publicado: (2023)

Engineered autocrine signaling eliminates muscle cell FGF2 requirements for cultured meat production
por: Stout, Andrew J., et al.
Publicado: (2023)

Epigenomic Control of Thermogenic Adipocyte Differentiation and Function
por: Peng, Xu, et al.
Publicado: (2018)

Thermogenic adipocytes: lineage, function and therapeutic potential
por: Pollard, Alice E., et al.
Publicado: (2020)

Transferrin Receptor Functionally Marks Thermogenic Adipocytes
por: Qiu, Jin, et al.
Publicado: (2020)

FGF21 regulates circadian behavior and metabolism by acting on the nervous system
por: Bookout, Angie L., et al.
Publicado: (2013)

Leptin: Is It Thermogenic?
por: Fischer, Alexander W, et al.
Publicado: (2019)

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding
por: Markan, Kathleen R., et al.
Publicado: (2014)

FGF7–FGFR2 autocrine signaling increases growth and chemoresistance of fusion‐positive rhabdomyosarcomas
por: Milton, Christopher I., et al.
Publicado: (2021)

Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes
por: Rajbhandari, Prashant, et al.
Publicado: (2019)

Isolation, Culture, and Functional Analysis of Murine Thermogenic Adipocytes
por: Oeckl, Josef, et al.
Publicado: (2020)

The thermogenic characteristics of adipocytes are dependent on the regulation of iron homeostasis
por: Yook, Jin-Seon, et al.
Publicado: (2021)

Therapeutic Perspectives of Thermogenic Adipocytes in Obesity and Related Complications
por: Wang, Chih-Hao, et al.
Publicado: (2021)

Integrins and extracellular matrix proteins modulate adipocyte thermogenic capacity
por: Gonzalez Porras, Maria A., et al.
Publicado: (2021)

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport
por: Bartelt, Alexander, et al.
Publicado: (2017)

Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3
por: Reilly, Shannon M., et al.
Publicado: (2020)

Thermogenic Ability of Uncoupling Protein 1 in Beige Adipocytes in Mice
por: Okamatsu-Ogura, Yuko, et al.
Publicado: (2013)

Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming
por: Guilherme, Adilson, et al.
Publicado: (2017)

3-Iodothyronamine Affects Thermogenic Substrates’ Mobilization in Brown Adipocytes
por: Gencarelli, Manuela, et al.
Publicado: (2020)

Thermogenic crosstalk occurs between adipocytes from different species
por: Gilor, Chen, et al.
Publicado: (2019)

Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes
por: Chaurasia, Bhagirath, et al.
Publicado: (2020)

PARP12 is required for mitochondrial function maintenance in thermogenic adipocytes
por: Hu, Fan, et al.
Publicado: (2022)

Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473
por: Tran, Khanh-Van, et al.
Publicado: (2020)

The effect of TGFβ1 on thermogenic markers is dependent on the degree of adipocyte differentiation
por: Maharjan, Babu R., et al.
Publicado: (2020)

FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p
por: Zhang, Jinglin, et al.
Publicado: (2018)

GSK3 is a negative regulator of the thermogenic program in brown adipocytes
por: Markussen, Lasse K., et al.
Publicado: (2018)

Effects of Pharmacological Thermogenic Adipocyte Activation on Metabolism and Atherosclerotic Plaque Regression
por: Worthmann, Anna, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_f76tofbcdblr2b8ego0hp92fpk