Lopinavir and Nelfinavir Induce the Accumulation of Crystalloid Lipid Inclusions within the Reservosomes of Trypanosoma cruzi and Inhibit Both Aspartyl-Type Peptidase and Cruzipain Activities Detected in These Crucial Organelles

Several research groups have explored the repositioning of human immunodeficiency virus aspartyl peptidase inhibitors (HIV-PIs) on opportunistic infections caused by bacteria, fungi and protozoa. In Trypanosoma cruzi, HIV-PIs have a high impact on parasite viability, and one of the main alterations...

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Detalles Bibliográficos
Autores principales: Sangenito, Leandro S., Pereira, Miria G., Souto-Padron, Thais, Branquinha, Marta H., Santos, André L. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293474/
https://www.ncbi.nlm.nih.gov/pubmed/34287373
http://dx.doi.org/10.3390/tropicalmed6030120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293474/
https://www.ncbi.nlm.nih.gov/pubmed/34287373
http://dx.doi.org/10.3390/tropicalmed6030120

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