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NLRP3 inhibition attenuates early brain injury and delayed cerebral vasospasm after subarachnoid hemorrhage

BACKGROUND: The NLRP3 inflammasome is a critical mediator of several vascular diseases through positive regulation of proinflammatory pathways. In this study, we defined the role of NLRP3 in both the acute and delayed phases following subarachnoid hemorrhage (SAH). SAH is associated with devastating...

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Detalles Bibliográficos
Autores principales: Dodd, William S., Noda, Imaray, Martinez, Melanie, Hosaka, Koji, Hoh, Brian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293512/
https://www.ncbi.nlm.nih.gov/pubmed/34284798
http://dx.doi.org/10.1186/s12974-021-02207-x