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Multi-Target Effects of the Cannabinoid CP55940 on Familial Alzheimer’s Disease PSEN1 E280A Cholinergic-Like Neurons: Role of CB(1) Receptor

BACKGROUND: Alzheimer’s disease (AD) is characterized by structural damage, death, and functional disruption of cholinergic neurons (ChNs) as a result of intracellular amyloid-β (Aβ) aggregation, extracellular neuritic plaques, and hyperphosphorylation of protein tau (p-Tau) overtime. OBJECTIVE: To...

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Detalles Bibliográficos
Autores principales: Soto-Mercado, Viviana, Mendivil-Perez, Miguel, Jimenez-Del-Rio, Marlene, Velez-Pardo, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293648/
https://www.ncbi.nlm.nih.gov/pubmed/33252082
http://dx.doi.org/10.3233/JAD-201045