Evaluation of SAMP8 Mice as a Model for Sleep-Wake and Rhythm Disturbances Associated with Alzheimer’s Disease: Impact of Treatment with the Dual Orexin (Hypocretin) Receptor Antagonist Lemborexant

BACKGROUND: Many patients with Alzheimer’s disease (AD) display circadian rhythm and sleep-wake disturbances. However, few mouse AD models exhibit these disturbances. Lemborexant, a dual orexin receptor antagonist, is under development for treating circadian rhythm disorders in dementia. OBJECTIVE:...

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Detalles Bibliográficos
Autores principales: Beuckmann, Carsten T., Suzuki, Hiroyuki, Musiek, Erik S., Ueno, Takashi, Sato, Toshitaka, Bando, Masahiro, Osada, Yoshihide, Moline, Margaret
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293654/
https://www.ncbi.nlm.nih.gov/pubmed/33843668
http://dx.doi.org/10.3233/JAD-201054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293654/
https://www.ncbi.nlm.nih.gov/pubmed/33843668
http://dx.doi.org/10.3233/JAD-201054

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